Cart
sales@molnova.com
Etacrynic acid
CAS No. 58-54-8
Etacrynic acid( Edecrin )
Catalog No. M15149 CAS No. 58-54-8
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 28 | In Stock |
|
| 50MG | 41 | In Stock |
|
| 100MG | 70 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameEtacrynic acid
-
NoteResearch use only, not for human use.
-
Brief DescriptionA loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
-
DescriptionA loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue; shows anticancer activity, and also is a potent inhibitor of glutathione S-transferase; shows antitumor effects and may enhance the cytotoxicity of chemotherapeutic agents by binding to glutathione and inhibiting WNT signaling.Other Indication Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsEdecrin
-
PathwayMAPK/ERK Signaling
-
TargetMEK
-
RecptorNKCC2|GST
-
Research AreaOther Indications
-
IndicationOther Disease
Chemical Information
-
CAS Number58-54-8
-
Formula Weight303.135
-
Molecular FormulaC13H12Cl2O4
-
Purity>98% (HPLC)
-
SolubilityEthanol: 30 mg/mL; DMSO: 30 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESCCC(=C)C(=O)C1=C(C(=C(C=C1)OCC(=O)O)Cl)Cl
-
Chemical NameAcetic acid, [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]- (9CI)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chan AI, et al. J Am Chem Soc. 2017 Aug 2;139(30):10192-10195.
2. Wang R, et al. Clin Cancer Res. 2012 Dec 15;18(24):6690-701.
3. Bryant ZE, et al. Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5.
4. Liu B, et al. Oncotarget. 2016 Sep 6;7(36):58038-58050.
molnova catalog
related products
-
Etacrynic acid
A loop diuretic used to treat high blood pressure and the swelling, a novel ligand and inhibitor of MAP2K6 kinase that inhibits MAP2K6 in part through alkylation of a nonconserved cysteine residue.
-
RO4987655
A potent and highly selective small-molecule MEK inhibitor with IC50 of 5.2 nM.
-
PD-184352
A potent, ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, displays 100-fold more selective for MEK1/2 than MEK5.
